Maternal and neonatal screening methods for congenital cytomegalovirus infection

Diagnosis of Maternal and Congenital Cytomegalovirus Infection

Human cytomegalovirus (CMV) is one of the eight viruses belonging to the Herpesviridae family to infect humans. CMV belongs to the Betaherpesvirinae subfamily of viruses characterized by a restricted host spectrum, in vitro replication in fibroblasts of the natural host species in vivo, a slow replication cycle, the induction of intranuclear and intracytoplasmic inclusions and the ability to in...

Congenital cytomegalovirus infection: predisposing maternal factors.

In a prospective study of cytomegalovirus (CMV) infection in pregnancy 69 congenitally infected infants were identified. The age, race, marital status, social class, and parity of the mothers of congenital CMV infants were compared with those of the screened population of women with non-infected infants. These factors were all individually strongly associated with the prevalence of congenital C...

Congenital cytomegalovirus infection--a question of screening.

• Vol 9 • May 2007 392 Routine serologic screening of pregnant women or newborns has never been recommended by any public health authority in any country. As a result of demands by pregnant women and the fear of litigation, most obstetricians in Israel do test pregnant women for cytomegalovirus, and they are confused by the findings. CMV infection is the most frequent congenital infection, affe...

Maternal immunity and prevention of congenital cytomegalovirus infection.

CONTEXT Vaccine development to prevent congenital cytomegalovirus (CMV) infection has been impeded by the uncertainty over whether maternal immunity protects the fetus. OBJECTIVE To determine whether the presence of maternal antibodies to CMV significantly reduces the risk of congenital CMV infection in future pregnancies. DESIGN, SETTING, AND PARTICIPANTS Cohort study of 3461 multiparous w...

Screening Newborns for Congenital Cytomegalovirus